- Johnny Depp/Thomas McDonell as Barnabas Collins
- Eva Green as Angelique
- Bella Heathcote as Victoria Winters/Josette DuPres
- Jackie Earle Haley as Willie Loomis
- Helena Bonham Carter as Dr. Julia Hoffman
- Chloe Moretz as Carolyn Stoddard
- Michelle Pfeiffer as Elizabeth Collins Stoddard
- Jonny Lee Miller as Roger Collins
- Gulliver McGrath as David Collins
Two centuries later, Barnabas is inadvertently freed from his tomb and emerges into the very changed world of 1972. He returns to Collinwood Manor to find that his once-grand estate has fallen into ruin. The dysfunctional remnants of the Collins family have fared little better, each harboring their own dark secrets. Matriarch Elizabeth Collins Stoddard (Michelle Pfeiffer) has called upon live-in psychiatrist, Dr. Julia Hoffman (Helena Bonham Carter), to help with her family troubles.
Also residing in the manor is Elizabeth's ne'er-do-well brother, Roger Collins (Jonny Lee Miller); her rebellious teenage daughter Carolyn Stoddard (Chloe Moretz); and Roger's precocious 10-year-old son, David Collins (Gulliver McGrath). The mystery extends beyond the family, to caretaker Willie Loomis, played by Jackie Earle Haley, and David's new nanny, Victoria Winters, played by Bella Heathcote.